9 edition of The Glutamate Receptors (The Receptors) found in the catalog.
February 15, 2008
by Humana Press
Written in English
|Contributions||Robert W. Gereau IV (Editor), Geoffrey Swanson (Editor)|
|The Physical Object|
|Number of Pages||580|
David Jane, in xPharm: The Comprehensive Pharmacology Reference, Target Structure Protein Information. The ionotropic glutamate (iGlu) receptors are multimeric assemblies of either four or five subunits, and are subdivided into three groups NMDA, AMPA, and kainate receptors based on their pharmacology and amino acid sequence homology Krogsgaard-Larsen et al (). The dark ages. Glutamate was an important intermediary metabolite in brain, but a transmitter? Hardly!. A transmitter function of L-glutamate did indeed seem quite unlikely in those early hypothetical ‘receptor' would have to respond to many amino acids (either L - or D-, ‘natural' or ‘unnatural') with some general resemblance to glutamate.
Glutamate receptor agonists and antagonists are structurally similar to glutamate (Fig. 4), which allows them to bind onto glutamate receptors. These compounds are highly specific and, even in intact tissue, can be used in very low concentrations because they are poor substrates for glutamate uptake systems (Tachibana and Kaneko, , Schwartz. The Ionotropic Glutamate Receptors conveys the first clear insights into the molecular bases underlying the wealth of pharmacological and physiological data on these receptors. Enter your mobile number or email address below and we'll send you a link to download the free Kindle App. Then you can start reading Kindle books on your smartphone Format: Hardcover.
The Metabotropic Glutamate Receptors offers state-of-the-art summaries and reviews of virtually everything known today about metabotropic glutamate receptors (mGluRs), including their molecular biology, pharmacology, anatomical distribution, and physiological and pathological roles. Glutamate clearance is necessary for proper synaptic activity and to prevent neuronal damage from excessive activation of glutamate receptors. Excitatory amino-acid transporters, or EAATs, regulate glutamate clearance, and are responsible for most of the glutamate uptake within the brain.
From the reviews: "This is intended as a comprehensive primer for scientists and students studying the glutamate receptors. The book provides a good working knowledge of these receptors for all potential neuroscientist readers.
it likely will best serve as a review for active researchers in the field of neuroscience. this book provides a timely update reflecting significant. From the reviews: "This is intended as a comprehensive The Glutamate Receptors book for scientists and students studying the glutamate receptors.
The book provides a good working knowledge of these receptors for all potential neuroscientist readers. it likely will best serve as a review for active researchers in the field of neuroscience. this book provides a timely update reflecting significant Manufacturer: Humana.
This book provides an expansive review of the field with a topical update to two excellent books - The Ionotropic Glutamate Receptors and The Metabotropic Glutamate Receptors. A primer to the study of glutamate receptors and their central role in neurotransmission.\/span>\"@ en\/a>.
The Glutamate Receptors provides an expansive review of the field with a topical update to two excellent books - The Ionotropic Glutamate Receptors and The Metabotropic Glutamate Receptors. An exciting primer to the study of glutamate receptors and their central role in neurotransmission, The Glutamate Receptors covers the extraordinary.
Adrien Didelot, Jérôme Honnorat, in Handbook of Clinical Neurology, NMDAr-Abs. NMDAr-Abs target the N-terminal extracellular domain of the NR1 subunit of the glutamate receptor NMDA and hamper the glutamatergic pathway by internalizing this receptor (Dalmau et al., The Glutamate Receptors book, ).NMDAr-Abs are present in patient’s sera and CSF as well, the latter showing a high antibody concentration.
Glutamate is a nonessential amino acid that does not cross the blood-brain barrier and must be synthesized in neurons from local precursors. The most prevalent glutamate precursor in synaptic terminals is glutamine.
Glutamine is released by glial cells and, once within presynaptic terminals, is metabolized to glutamate by the mitochondrial enzyme glutaminase (). For ionotropic glutamate receptors, the agonist-binding sites and associated ion channels are incorporated into the same macromolecular complex.
Agonists increase the probability that the channel will open, and the three classes of ionotropic receptor originally were named after reasonably selective agonists: N-methyl-d-aspartate (NMDA), α-aminohydroxymethylisoxazole propionic acid Cited by: 2. Glutamate receptor activation-mediated excitotoxicity has been hypothesized to cause cell death in both acute and chronic neurodegenerative diseases including glaucoma.
Although the precise mechanisms of ischemia-induced neuronal death are unknown, glutamate excitotoxicity-induced apoptotic cell death is considered to be an important component. Most of the information presented in this section regarding glutamate and its receptors can be found in Kandel’s book.
Tan, HOPES is a team of faculty and undergraduate students at Stanford University dedicated to making scientific information about Huntington’s disease (HD) more readily accessible to the public. The Glutamate Receptors by Robert W. Gereau,available at Book Depository with free delivery worldwide.
This volume aims to provide clear and detailed methods to probe glutamate receptor function. Chapters in this book feature methods to study synaptic ultrastructure, receptor dynamics/receptor interactions and trafficking, cellular plasticity, receptor gene regulation, epigenetics, and clinical applications.
Glutamate is an Excitotoxin. Excitotoxins are a group of chemicals that when ingested, damage the neurons. The most well known excitotoxin would probably be MSG, an additive that enhances the flavor of food.
Excitotoxicity occurs when receptors for the excitatory neurotransmitter glutamate are. Glutamate receptors (GluRs) in the central nervous system have been the subject of intense investigations for several decades, providing new avenues for. This book is an excellent review of the molecular biology, pharmacology, anatomical distribution, and physiological and pathological roles of metabotrophic glutamate receptors.
It provides a substantial support for the knowledge of metabotrophic glutamate receptor role in 2/5(1). Part of the Handbook of Experimental Pharmacology book series (HEP, volume ) Log in to check access. Buy eBook.
USD Instant download; Readable on all devices Molecular Structure of Glutamate Receptors. Front Matter. Pages PDF. Structure of Ionotropic Glutamate Receptors.
Hollmann. Pages Phosphorylation of Glutamate. Glutamate is the major excitatory neurotransmitter in the nervous system. Glutamate pathways are linked to many other neurotransmitter pathways, and glutamate receptors are found throughout the brain and spinal cord in neurons and glia.
As an amino acid and neurotransmitter, glutamate has a large array of normal physiological functions. The book surveys the distribution of receptor subtypes for the classical monoamine transmitters (acetylcholine, adrenaline, noradrenaline and serotonin) as well as the distribution of receptors for the excitatory and inhibitory amino acids, (glutamate, GABA and benzodiazepines) as well as the opioid peptides, angiotensen and other neuropeptides.
Chapters 3 through 6 deal with glutamate receptors. Metabotropic glutamate receptors are presented in Chapter 3. Chapter 4 presents an in situ hybridization atlas of the different classes of ionotropic glutamate receptors.
The localizations of these receptors at the regional and synaptic level are presented in Chapter /5(1). Metabotropic glutamate receptors are family C G-protein-coupled receptors. They form obligate dimers and possess extracellular ligand-binding.
Optical control of glutamate receptors with temporal resolution and genetic specificity: from molecules to systems. Optical techniques afford a high temporal precision. PTLs allow particularly precise control, since the photoisomerization of azobenzene is a picosecond process and binding is.
Biochemical receptors for glutamate fall into three major classes, known as AMPA receptors, NMDA receptors, and metabotropic glutamate receptors.A fourth class, known as kainate receptors, are similar in many respects to AMPA receptors, but much less synapses use multiple types of glutamate receptors.
AMPA receptors are ionotropic receptors specialized for fast excitation: in.The Glutamate Receptors provides an expansive review of the field with a topical update to two excellent books - The Ionotropic Glutamate Receptors and The Metabotropic Glutamate Receptors.
An exciting primer to the study of glutamate receptors and their central role in neurotransmission, The Glutamate Receptors covers the extraordinary Book Edition: 1.Glutamate receptor antagonists can be broadly divided into two types: agents that block the NMDA receptor and those that block the AMPA receptor.
Antagonists of the NMDA receptor act either by competitive antagonism at the glutamate-binding site or by noncompetitive antagonism at the glycine, phencyclidine (PCP)- and magnesium-binding sites.